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In clinical trials, Chentix was generally well tolerated.
However, there were side effects that were more general in
occurrence and some that were more serious, but rare.
Gastrointestinal Side Effects: The most common side
effect of taking Chantix is nausea. Other
gastrointestinal
symtoms include abdominal pain, gas, dyspepsia, vomiting,
constipation, acid reflux, and dry mouth.
Psychiatric Side Effects: Psychiatric disorders
involved problems with sleep disorders such as insomnia,
abnormal dreams and nightmares.
Nervous Systems
Side
Affects: Nervous system problems
involved headache, somnolence, and lethargy.
General disorders included fatigue, malaise, and asthenia.
Metabolism Side Effects: Metabolism and nutritional
side effects included either increased or decreased appetite
and anorexia.
Other side effects involved skin rash and respiratory
disorders.
More serious, but less common were life threatening side
affects which may or may not require medical attention
depending on severity of symptoms and life threatening
nature. Those include, nut are not limited to, blood and
lymphatic system disorders (anemia), cardiac disorders
(chest pain, heart arrhythmia, heart palpitations and rapid
heartbeat, stroke, atrial fibrillation, and coronary heart
disease), ear disorders (tinitus, vertigo), thyroid gland
disorders, gastrointestinal disorders (diarrhea, gingivitis,
gastritis, esophagitis, gastric ulcer), immune systems
disorders, metabolism disorder (diabetes), musculoskeletal
(back pain, muscle cramps, musculoskeletal pain, arthritis,
osteoporosis), nervous system disorders (disturbance in
attention, dizziness, amnesia, migraine, restless leg
syndrome, tremor), psychiatric disorders (anxety
depression, irritability, restlessness, mood swings,
agitation, decreased libido). There is a low occurrence of
renal and urinary disorders, reproductive disorders
(menstrual disorder, erectile dysfunction), vascular
disorders (hot flush, hypertension, hypotension),
respiratory disorders, and skin disorders (acne, dermatitis,
dry skin, eczema, psoriasis).
Chantix has no clinically significant pharmacological drug
interactions and was shown not to have carcinogenic effects
in studies on rats.
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